Status:
COMPLETED
Lung Protective One-lung Ventilation With Fix and Variable Tidal Volume
Lead Sponsor:
University of Debrecen
Conditions:
Hypoxemia
Pulmonary Sepsis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
During One-lung ventilation, the use of lower tidal volumes (VT) is helpful to avoid over-distension, provide sufficient oxygenation, but can result in increased atelectasis. Nevertheless, it is not ...
Detailed Description
Lung separation will be performed by DLT technique. Mechanical ventilation will be applied in volume-controlled mode. During two-lung ventilation, VT will be set at 8 mL/kg predicted body weight. Duri...
Eligibility Criteria
Inclusion
- Patient scheduled for open thoracic or video-assisted thoracoscopic surgery under general anesthesia requiring OLV (no emergency surgery)
- BMI \< 35 kg/m2
- Age ≥ 18 years
- Expected duration of surgery \> 60 min
- Expected duration of anesthesia \> 90 min
Exclusion
- COPD GOLD 3+4, lung fibrosis, documented bullae, severe emphysema, pneumothorax
- uncontrolled asthma
- NYHA 3+4, CCS 3+4
- previous thoracic surgery
- ARDS (Berlin definition)
- documented pulmonary arterial hypertension \> 40 mmHg syst
- documented or suspected neuromuscular disease (thymoma, myasthenia)
- planned mechanical ventilation after surgery
- bilateral procedures
- lung separation with other method than DLT (eg diff. airway, tracheostomy)
- surgery in prone position
- persistent hemodynamic instability, intractable shock
- intracranial injury or tumor
- enrollment in other interventional study or refusal of informed consent
- pregnancy (excluded by anamnesis and/or laboratory analysis)
Key Trial Info
Start Date :
February 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
April 1 2018
Estimated Enrollment :
140 Patients enrolled
Trial Details
Trial ID
NCT03364465
Start Date
February 1 2017
End Date
April 1 2018
Last Update
April 16 2019
Active Locations (1)
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1
University of Debrecen, Department of Anesthesiology and Intensive Care
Debrecen, Hungary, 4032