Status:
UNKNOWN
Anticoagulation Therapies Effect on the Endometrial Blood Flow and Pregnancy Outcomes in Unexplained Recurrent Implantation Failure Women
Lead Sponsor:
Shanghai First Maternity and Infant Hospital
Conditions:
Recurrent Implantation Failure
Eligibility:
FEMALE
25-45 years
Brief Summary
The aim of the study is to investigate whether Low Dose Aspirin and Low Molecular Weight Heparin could increase the uterine perfusion, and finally improve the implantation and pregnancy rates in patie...
Detailed Description
Infertility is a growing issue for many couples all over the world. Nowadays, Assisted reproductive technology is widely used to treat couples affected by infertility, but, the success rate is still v...
Eligibility Criteria
Inclusion
- ≥3 pervious IVF-ET failures or failure with transfer of at least 10 frozen embryos in multiple transfers;
- 25-45 years old;
- Having a regular menstrual cycle and BBT;
- Top-quality frozen embryos for transfer;
- Endometrial thickness 8-14mm；
- Abnormal uterine perfusion(PI\>2.5)；
- Decided to recieve LMWH or LDA or a combination of LMWH and LDA therapy.
Exclusion
- Chromosome aberrations in anyone of the couple;
- Abnormal uterine cavity;
- Hydrosalpinx;
- Chronic systemic disease(liver,renal,heart,thyroid and thrombocytopenia)
- Having experienced severe allergies, trauma history；
- With a history of mental illness;
- Any contraindication for LDA or LMWH.
Key Trial Info
Start Date :
December 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 1 2019
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03365466
Start Date
December 1 2017
End Date
February 1 2019
Last Update
December 7 2017
Active Locations (1)
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1
Shanghai first Maternity and Infant health hospital, Tong Ji University
Shanghai, China, 200051