Status:
WITHDRAWN
A Breathing-Based Meditation Intervention for Patients With Treatment Resistant Late Life Depression
Lead Sponsor:
London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Conditions:
Late Life Depression
Eligibility:
All Genders
60-80 years
Phase:
PHASE1
Brief Summary
Late-life depression affects 2-8% of seniors and causes high rates of caregiver distress and risk of suicide. To exacerbate the problem, antidepressants, the cornerstone of therapy, are resistant in 5...
Detailed Description
RECRUITMENT AND CONSENT: Patients will be recruited from Victoria Hospital, London Health Sciences Centre or Parkwood Mental Health, St. Joseph's Health Care London. Patients will be screened and rec...
Eligibility Criteria
Inclusion
- 60-80 years of age
- major depressive disorder, as per the results of an interview by a trained rater using the Structured Clinical Interview for DSM-5 and subsequently confirmed by the psychiatrist
- Mild to moderate depression as confirmed by a score on the HAM-D 17 between 8 and 23
- Have failed at least two trials of antidepressants, given at adequate doses for adequate duration during the current episode
- Able to follow verbal instructions and sit without physical discomfort for 45 minutes
- Willing and able to attend at least 75% of all Sudarshan Kriya Yoga (SKY) sessions
- Willing to dedicate 25-30 minutes/day to SKY practice at home
- Low risk of suicide based on a clinical initial interview and during follow-up interviews at weeks 4, 8 and 12.
Exclusion
- Uncontrolled hypertension, seizure disorder, psychosis, substance abuse, or dementia
- Currently participating in other similar studies or currently practicing any type of formal meditation, mindfulness or breathing techniques
- A major surgery within 6 weeks prior to commencement of or scheduled during, the study intervention
- A traumatic brain injury
- Any contraindications to MRI will also be excluded
- Healthy control participants must have no significant mental health issues, or contraindications to MRI.
Key Trial Info
Start Date :
January 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 31 2022
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03368560
Start Date
January 1 2020
End Date
December 31 2022
Last Update
June 25 2018
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