Status:
ACTIVE_NOT_RECRUITING
Effect of Teriflunomide Treatment on Microglial Activation in an MS Patient Cohort at Risk of Progression
Lead Sponsor:
Turku University Hospital
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
40-55 years
Brief Summary
To evaluate the effect of teriflunomide treatment on microglial activation in late stage multiple sclerosis.
Detailed Description
In Multiple Sclerosis (MS), plaques in the white and grey matter of the brain represent the best known pathological changes of the disease, but a significant inflammation process has also been detecte...
Eligibility Criteria
Inclusion
- Signing the consent form
- Having used teriflunomide treatment for at least 6 months
- 40-55 years of age at the time of signing the research consent form
- MS diagnosis in accordance with either the Poser or McDonald criteria
- EDSS 2-6.5
- Clear lesion load in brain MRI (\> 9 T2 lesion)
Exclusion
- Patients suffering from another brain disease of in addition to multiple sclerosis
- Steroid treatment 4 weeks prior to the scan
- Significant pathology in the MRI scan other than MS-related lesions
- Patients suffering from claustrophobia or panic disorder, or patients who have exhibited hypersensitivity of PET markers (practical obstacle to the scan)
- Exposure to experimental radioactivity in the last 12 months such that the dosimetry threshold would be exceeded due to participation in the study
- Severe hepatic impairment
- Pregnant women, or women of childbearing potential who are not using reliable contraception during treatment with teriflunomide and thereafter as long as its plasma levels are above 0.02 mg/l.
Key Trial Info
Start Date :
December 1 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2027
Estimated Enrollment :
26 Patients enrolled
Trial Details
Trial ID
NCT03368677
Start Date
December 1 2017
End Date
December 1 2027
Last Update
April 13 2025
Active Locations (1)
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1
Turku PET Centre
Turku, Southwest Finland, Finland, 20520