Status:
COMPLETED
Implication of the Oxydative Stress in the Pathophysiology of Sickle Cell Anemia:
Lead Sponsor:
Centre Hospitalier Universitaire de la Guadeloupe
Conditions:
Sickle Cell Disease
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Despite important advances in the current understanding of sickle cell vaso-occlusion, the basis of its control and prevention remain partially unknown. The primary purpose is to test the hypothesis o...
Detailed Description
Although oxidative stress is not the primary aetiology of SCA, oxidative damage could in part account for pathophysiological mechanisms leading to sickle vaso-occlusion, in which anti bande 3 antibodi...
Eligibility Criteria
Inclusion
- \- adults ≥ 18 years old SCA patients (SS genotype) hospitalized for bone VOC with single or multifocal localizations.
Exclusion
- chronic transfusion therapy or recent blood transfusion (less than 3 months before the current VOC or the state defined "steady-state" in SCA);
- severe chronic renal failure; liver failure;
- autoimmune disease;
- viral hepatitis; HIV seropositivity;
- pregnancy or breast feeding;
- patients already engaged in another therapeutic clinical research protocol; - non-compliant patients to usual care;
- patients unable to give their consent.
Key Trial Info
Start Date :
April 9 2013
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 19 2015
Estimated Enrollment :
38 Patients enrolled
Trial Details
Trial ID
NCT03368924
Start Date
April 9 2013
End Date
September 19 2015
Last Update
December 11 2017
Active Locations (1)
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1
Hospital University Center of Pointe-à-Pitre
Pointe-à-Pitre, Guadeloupe, 97159