Status:
ACTIVE_NOT_RECRUITING
Mechanisms of Disease Severity in Multiple Sclerosis: an Integrative Multimodal Study
Lead Sponsor:
Institut National de la Santé Et de la Recherche Médicale, France
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18+ years
Brief Summary
This study will identify a combination of disease severity markers (genetic, immunology, epigenetic, imaging) associated with disease severity and progression in a cohort of patients with multiple scl...
Detailed Description
The heterogeneity of multiple sclerosis evolution relies on several pathophysiological mechanisms including neuroinflammation, neurodegeneration and remyelination and repair mechanisms. The study wil...
Eligibility Criteria
Inclusion
- Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria)
- Sibling having Clinically isolated syndrome or Multiple sclerosis (2010 Mc Donald criteria) willing to participate to the study
- Affiliated to the French social security or equivalent
Exclusion
- Cyclophosphamide, mitoxantrone or methylprednisolone infusion within one month before inclusion
- Multiple sclerosis relapse within one month before inclusion
- Concomitant severe or uncontrolled disease
Key Trial Info
Start Date :
February 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
February 5 2026
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT03369106
Start Date
February 6 2018
End Date
February 5 2026
Last Update
March 5 2025
Active Locations (1)
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1
CIC Neurosciences Institut du Cerveau et de la Moelle Epinière
Paris, France, 75013