Status:
COMPLETED
Nitrate and Exercise Performance in Middle to Older Aged Adults
Lead Sponsor:
Wake Forest University
Collaborating Sponsors:
Isagenix International LLC
Conditions:
Aging
Eligibility:
All Genders
40-65 years
Phase:
NA
Brief Summary
Research with young healthy individuals has shown that beetroot juice beverages that contain large amounts of nitrate can improve exercise performance. Currently, it is not know whether the consumptio...
Detailed Description
Nitric oxide (NO) has been identified as an important biological messenger involved in a number of physiological processes and is produced from L-arginine and molecular oxygen by NO-synthases or the m...
Eligibility Criteria
Inclusion
- Competitive runner or cyclist.
- Able to pedal a stationary bike.
- Engage in moderate physical activity for at least 150 minutes per week or engage in strenuous physical activity for at least 75 minutes per week.
- Able to provide own transportation to study testing visits.
- Able to provide own transportation to study testing visits.
- Able to consume study beverages.
- Willingness to provide informed consent and participate in the intervention.
Exclusion
- tobacco user (smoke or chew)
- participating in another intervention research study
- diabetes (type 1 or 2)
- atrophic gastritis
- hypo-or hyperthyroidism
- gout
- history of kidney stones
- history of hypotension
- aversion to the study-related testing procedures
- allergy/sensitivity/aversion to beetroot beverages
- medical conditions with contraindications for engaging in the vigorous aerobic exercise
- current treatment for cancer
- thyroid disorders,
- cardiovascular disease,
- chronic obstructive pulmonary disease,
- inflammatory bowel diseases
- impaired liver or kidney function
- taking phosphodiesterase type 5 inhibitors
- taking nitroglycerin or nitrate preparations
- taking proton pump inhibitors
- taking medication for hypothyroidism
Key Trial Info
Start Date :
December 13 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 18 2019
Estimated Enrollment :
29 Patients enrolled
Trial Details
Trial ID
NCT03371966
Start Date
December 13 2017
End Date
January 18 2019
Last Update
May 6 2019
Active Locations (1)
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1
Wake Forest University
Winston-Salem, North Carolina, United States, 27109