Status:
COMPLETED
Essential Amino Acids and Protein Kinetics During Caloric Deprivation
Lead Sponsor:
United States Army Research Institute of Environmental Medicine
Collaborating Sponsors:
University of Arkansas
Eastern Michigan University
Conditions:
Muscle Protein Synthesis
Whole-body Protein Balance
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
The amount of essential amino acids (EAA) necessary to maximally stimulate muscle protein synthesis and optimize whole-body net protein balance during caloric deprivation has not been determined. This...
Detailed Description
Short-term negative energy balance downregulates muscle protein synthesis and upregulates whole-body proteolysis and amino acid (AA) oxidation, thereby increasing nitrogen excretion and exacerbating w...
Eligibility Criteria
Inclusion
- Men and women aged 18 - 35 years
- Body mass index \< 30.0 kg/m2
- Healthy without evidence of chronic illness or musculoskeletal injury as determined by the USARIEM Office of Medical Support and Oversight (OMSO)
- Resistance exercise trained defined by self-report as performing ≥ 2 sessions/wk for previous 6 mo
- Refrain from taking any nonsteroidal anti-inflammatory drugs (e.g., aspirin, Advil®, Aleve®, Naprosyn®), or any other aspirin-containing product for 10 days before starting and at least 5 days after completing the study
- Willing to refrain from alcohol, smoking any nicotine product (includes e-cigarettes); vaping, chewing tobacco, caffeine, and dietary supplement use throughout the entire study period
- Supervisor approval for federal civilian employees and non-HRV active duty military personnel working within the US Army Natick Soldier Systems Center
Exclusion
- Musculoskeletal injuries that compromise exercise capability as determined by the USARIEM Office of Medical Support and Oversight (OMSO)
- Metabolic or cardiovascular abnormalities, gastrointestinal disorders (e.g., kidney disease, diabetes, cardiovascular disease, etc.)
- Abnormal PT/PTT test or problems with blood clotting
- History of complications with lidocaine
- Present condition of alcoholism, anabolic steroids, or other substance abuse issues
- Blood donation within 8-wk of beginning the study
- Pregnancy (self-report or results of urine pregnancy test before body composition testing)
- Unwillingness or inability to consume study diets or foods provided
Key Trial Info
Start Date :
September 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2019
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03372928
Start Date
September 1 2018
End Date
March 20 2019
Last Update
November 20 2020
Active Locations (1)
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1
US Army Research Institute of Environmental Medicine
Natick, Massachusetts, United States, 01760