Status:
COMPLETED
Functional Effects of Botox on the Brain Using MRS and fMRI
Lead Sponsor:
University of California, Irvine
Collaborating Sponsors:
Allergan
Conditions:
Healthy
Eligibility:
FEMALE
30-40 years
Phase:
PHASE4
Brief Summary
The injection of BOTOX into peripheral muscles has been shown to have therapeutic effects in a growing number of indications including disorders involving skeletal muscle (e.g., strabismus, blepharosp...
Detailed Description
Participants will receive one MRI scan session prior to a standardized, clinical dose of BOTOX injected into the forehead per FDA-approved procedures. Participants will then undergo a second MRI scan ...
Eligibility Criteria
Inclusion
- Females
- Ages 30-40 years of age
- Right-handed
- Normal or corrected-to-normal vision
- No history of psychiatric, neurological, or medical co-morbidities that might interfere with normal brain functioning
- Fluent in English
- Moderate to severe glabellar lines
Exclusion
- Pregnancy
- Ferrous metal, a pacemaker, or other battery-operated device implanted in the body
- Claustrophobia
- Known hypersensitivity to Botulinum Toxin
- Infection on the forehead or between the eyes
- Urinary tract infection
Key Trial Info
Start Date :
September 30 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 16 2018
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT03373162
Start Date
September 30 2017
End Date
March 16 2018
Last Update
June 1 2020
Active Locations (1)
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1
University of California, Irvine
Irvine, California, United States, 92697