Status:
COMPLETED
Efficacy of Amoxicillin-metronidazole Compared to Clindamycin in Patients With Periodontitis and Diabetes
Lead Sponsor:
Centro Universitario de Tonalá
Conditions:
Periodontitis
Periodontal Pocket
Eligibility:
All Genders
18-70 years
Phase:
PHASE3
Brief Summary
Periodontitis is an inflammation of the supporting structures of the teeth, usually caused by specific or groups of microorganisms that results in the progressive destruction of the periodontal ligament...
Detailed Description
A parallel, randomized, double-blind, active controlled, single center clinical trial was designed to compare the efficacy of two antibiotic therapies with 24-month follow-up. The study protocol was a...
Eligibility Criteria
Inclusion
- Patients of both sexes
- Age \>18 to 70 years
- Diagnosis of chronic periodontitis according to the 1999 International World Workshop for a Classification of Periodontal Diseases and Conditions
- History of type 2 diabetes
- HbA1C \< 8 %
- Fasting plasma glucose (FPG) \< 180 mg/dL.
Exclusion
- Aggressive periodontitis
- Pregnant or lactating females,
- Required antibiotic pre-medication for the performance of periodontal examination and treatment or received antibiotic treatment in the previous 3 months were excluded.
- A history of anti-inflammatory therapy within preceding six months
- Had received a course of periodontal treatment within the last 6 months,
- Allergies to penicillin, metronidazole or clindamycin,
- Not able to provide consent to participate in the study
Key Trial Info
Start Date :
March 1 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 1 2017
Estimated Enrollment :
42 Patients enrolled
Trial Details
Trial ID
NCT03374176
Start Date
March 1 2014
End Date
September 1 2017
Last Update
September 16 2020
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