Status:
COMPLETED
Interest of Oxygenated Hypothermic Perfusion (PHO) in Preservation of Hepatic Grafts From Expanded Criteria Donors
Lead Sponsor:
Rennes University Hospital
Conditions:
Hepatocellular Injury
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Interest of oxygenated hypothermic perfusion in preservation of hepatic grafts from expanded criteria donors.
Detailed Description
The excellent results of liver transplantation (LT) have led to a significant increase in the number of patients awaiting transplantation. At the same time, the number of grafts remains stable. To ext...
Eligibility Criteria
Inclusion
- Patients older than 18 years
- Candidates for a first orthotopic liver transplantation, without transplantation of another associated organ (kidney, pancreas, heart, lung, intestine)
- With cirrhosis whatever its etiology and gravity
- With or without hepatocarcinoma
- Having given free, informed and written consent
- LT made from a whole graft, harvested from a brain-dead donor with ECD criteria, defined as the presence of at least one of the following criteria:
- Age\> 65 years
- BMI\> 30 kg / m2
- Duration of hospitalization in intensive care unit\> 7 days
- Natremia\> 155 mmol / l
- AST\> 150 IU / ml
- ALT\> 170 IU / ml
- Occurrence of cardiac arrest before harvesting
- Macrovacuolar steatosis\> 30% on liver histology
Exclusion
- History of organ transplantation
- Transplantation in emergency
- Transplantation from a living donor, a reduced graft or a graft from a deceased donor by cardiac arrest (DCD)
- Major persons subject to legal protection (safeguard of justice, guardianship), persons deprived of their liberty
Key Trial Info
Start Date :
February 19 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 7 2019
Estimated Enrollment :
25 Patients enrolled
Trial Details
Trial ID
NCT03376074
Start Date
February 19 2018
End Date
February 7 2019
Last Update
March 11 2019
Active Locations (1)
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1
CHU de Rennes
Rennes, France, 35033