Status:
TERMINATED
Resection of the Esophagus and Subsequent Weight Loss
Lead Sponsor:
Imperial College London
Collaborating Sponsors:
University College Dublin
St. James's Hospital, Ireland
Conditions:
Esophageal Cancer
Weight Gain
Eligibility:
All Genders
18+ years
Brief Summary
The investigators aim to ascertain how food reward signals and eating behaviour relates to the gut-brain pathway in weight-losing patients after curative surgery for oesophageal cancer, and how this p...
Detailed Description
The incidence of cancer of the oesophagus (food pipe) is increasing. Improvements in treatment strategies have resulted in more people who remain free from cancer recurrence in the long term following...
Eligibility Criteria
Inclusion
- History of esophagectomy with gastric conduit reconstruction
- Recurrence-free at least 12 months post-operatively
- Weight loss ≥10% from premorbid weight, or requiring ongoing caloric supplementation
- Due to undergo clinical treatment for weight loss with Sandostatin or Mirtazapine
Exclusion
- Pregnancy, breastfeeding
- Significant and persistent chemoradiotherapy and/or surgical complication
- Other active malignancy
- Exocrine pancreatic insufficiency detected using fecal elastase
- Uncontrolled diabetes mellitus
- Significant psychiatric disorder or cognitive decline or communication impairment limiting capacity to provide informed consent
- Severe dysphagia
- Other disease or medication which may impact gut hormone physiology
- History of significant food allergy, certain dietary restrictions
- Any definite contraindication to somatostatin analogue administration
- Claustrophobia, or any absolute contraindication to MRI scanning
- Metallic implants, precluding fMRI
Key Trial Info
Start Date :
January 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
June 1 2023
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03377660
Start Date
January 1 2018
End Date
June 1 2023
Last Update
March 27 2024
Active Locations (1)
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1
Conway Institute, UCD
Dublin, Ireland