Status:
COMPLETED
Psoriatic Arthritis Research Collaborative: Biologic Sub-Study
Lead Sponsor:
University of Pennsylvania
Collaborating Sponsors:
The Cleveland Clinic
NYU Langone Health
Conditions:
Psoriatic Arthritis
Eligibility:
All Genders
18-89 years
Brief Summary
Psoriatic arthritis (PsA) is an inflammatory arthritis with substantial variation in clinical features. We propose a multicenter collaborative approach to better understand the phenotypes and current ...
Detailed Description
Psoriatic arthritis (PsA) is a chronic inflammatory arthritis that can be associated with devastating outcomes including irreversible joint damage. The management of a patient with PsA is extremely ch...
Eligibility Criteria
Inclusion
- Age 18-89
- Active PsA (at least one swollen joint or enthesitis) -Meet CASPAR criteria (Table 2) (103) -Initiation of TNFi (etanercept, adalimumab, infliximab, certolizumab, golimumab) (At the time of the submission, TNFi biosimilars have been approved by the FDA but are not available on the US market. Once available, patients starting TNFi biosimilars will similarly be eligible for participation. Patients may have been on the medication in the past but must have had greater than 2 months off the medication.Patients may be taking other traditional DMARDs. A washout period is not required.)
Exclusion
- Unable to give informed consent
- Out of the age range
- Switching therapies for skin psoriasis in the setting of well controlled joint and enthesis symptoms.
- Patients with only active PsA
Key Trial Info
Start Date :
December 31 2017
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
August 16 2023
Estimated Enrollment :
171 Patients enrolled
Trial Details
Trial ID
NCT03378336
Start Date
December 31 2017
End Date
August 16 2023
Last Update
May 9 2025
Active Locations (4)
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1
NYU School of Medicine
New York, New York, United States, 10003
2
Cleveland Clinic
Cleveland, Ohio, United States, 44195
3
Hospital at the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104
4
University of Utah
Salt Lake City, Utah, United States, 84132