Status:
COMPLETED
Tedizolid Prolonged Treatment for Prosthetic Joint Infections
Lead Sponsor:
Tourcoing Hospital
Collaborating Sponsors:
Eric SENNEVILLE M.D. Ph.D.
Conditions:
Prosthetic Joint Infection
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Pilot study the aim of which is to obtain reliable data on the tolerance, compliance and efficacy of Tedizolid used as prolonged (≥ 6 weeks) monotherapy or in combination therapy for the treatment of ...
Detailed Description
Background: The antibiotic treatment of patients with orthopedic device infections (e.g. prosthetic joint and osteosynthesis) is limited by the tolerance of prolonged administration of antibiotics and...
Eligibility Criteria
Inclusion
- Patient at least 18 years;
- Orthopedic device infection defined according to the French recommendations published in 2009 (Med Mal Infect 2009; 39:745-774) for which TEDIZOLID treatment is proposed according to the investigator's decision;
- Bacterial documentation of the infection will only be based on the results of reliable samples such as joint aspiration and peroperative samples.
- Requiring TEDIZOLID administration as a single antibiotic therapy or in combination therapy including another agent with proven activity against the involved pathogen(s);
- No contraindication to TEDIZOLID;
- Provide a signed informed consent for the trial.
Exclusion
- pregnant women or of childbearing age without contraception, breastfeeding,
- intolerance to TEDIZOLID;
- allergy to LINEZOLID;
- bactéria non susceptible to TEDIZOLID;
- patient with uncertainty regarding the possibility to achieve one-year follow-up after the end of treatment.
Key Trial Info
Start Date :
August 28 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 22 2021
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03378427
Start Date
August 28 2018
End Date
August 22 2021
Last Update
September 8 2021
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
Hôpital Ambroise Paré
Boulogne-Billancourt, France, 92380
2
Hôpital de la Croix Rousse
Lyon, France, 69004