Status:
COMPLETED
Bleeding in Knee Arthroplasty After Preconditioning With Sevoflurane
Lead Sponsor:
University of Sao Paulo General Hospital
Conditions:
Blood Loss, Surgical
Blood Transfusion
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
Knee arthroplasty is performed with restriction of blood flow by use of the pressure tourniquet. Ischemia of skeletal musculature is accompanied by the formation of reactive oxygen species and release...
Detailed Description
The use of pneumatic tourniquet allows a clear surgical field by restricting blood flow to the area to be operated, which implies at least intraoperative bleeding, but with a high risk of postoperativ...
Eligibility Criteria
Inclusion
- indication for knee arthroplasty
Exclusion
- Physical state according to classification from American Association of Anesthesiologists (ASA) III or higher,
- Obesity (body mass index, BMI, greater than 30),
- Renal insufficiency - patients on a dialysis program or with a serum creatinine level above 1.4 mg / dL,
- Hematocrit less than 30% or hemoglobin less than 10g / dL,
- Records of myocardial infarction during the last 6 months, unstable angina pectoris,
- History of coagulation disorders,
- Use of oral anticoagulants, heparin or acetylsalicylic acid in the last 5 days.
Key Trial Info
Start Date :
February 2 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 19 2020
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT03379103
Start Date
February 2 2018
End Date
December 19 2020
Last Update
February 25 2021
Active Locations (1)
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1
Hospital das Clínicas - Faculdade de Medicina da Universidade de Sao Paulo
São Paulo, Brazil, 01246-903