Status:
COMPLETED
Effect of Beetroot Juice on Blood Pressure Regulation in Post Menopausal Women
Lead Sponsor:
Penn State University
Conditions:
Postmenopausal Women
Eligibility:
FEMALE
55-80 years
Phase:
PHASE2
Brief Summary
In this study the investigators will test the hypothesis that acute consumption of inorganic nitrate (supplied in concentrated beetroot juice) reduces artery stiffness and resting blood pressure, and ...
Detailed Description
Postmenopausal women have stiff central arteries and exaggerated blood pressure (BP) responses during exercise compared with either premenopausal women or men of similar age. Arterial stiffness and ex...
Eligibility Criteria
Inclusion
- Resting systolic blood pressure less than or equal to 160 mmHg
- Resting diastolic blood pressure less than or equal to 100 mmHg
Exclusion
- Overt cardiovascular, metabolic, hematologic, pulmonary, renal, musculoskeletal, and/or neurological disease(s)
- Users of any tobacco and/or nicotine products (smokers, chewing tobacco, nicotine-containing patches/gum, smokeless cigarettes)
- Body mass index greater than 35
- Total cholesterol greater than 239 mg/dl
- LDL cholesterol greater than 159 mg/dl
- Fasting blood triglycerides greater than 199 mg/dl
- Fasting blood glucose greater than 109 mg/dl and HbA1c greater than 6.0%
- Individuals currently taking any of the following medications:
- blood pressure lowering medication (e.g., beta blockers, ACE inhibitors, angiotensin antagonists, calcium channel blockers, diuretics)
- lipid-lowering medication (e.g., statins)
- nitrates (e.g. nitroglycerin) for angina
- phosphodiesterase inhibitors (e.g., Viagra)
- anti-inflammatory drugs
- Individuals currently taking hormone replacement therapy
Key Trial Info
Start Date :
September 12 2014
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 1 2020
Estimated Enrollment :
16 Patients enrolled
Trial Details
Trial ID
NCT03380000
Start Date
September 12 2014
End Date
January 1 2020
Last Update
July 12 2022
Active Locations (1)
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1
Penn State University
University Park, Pennsylvania, United States, 16802