Status:
UNKNOWN
Conditioning Based Intervention Strategies
Lead Sponsor:
University of Aarhus
Conditions:
Ischemic Preconditioning
Eligibility:
MALE
18-80 years
Phase:
NA
Brief Summary
The overall objective of this study is to uncover and utilize the mechanisms behind the activation of endogenous organ protection by remote ischemic conditioning (RIC), high intensity traditional resi...
Detailed Description
Background Clinical background - ischemia related and inflammatory conditions The pandemic of cardiovascular disease has immense negative effects on global population health and life expectancy. The ...
Eligibility Criteria
Inclusion
- Able to understand the written and spoken information and to give informed consent for inclusion.
- Age between 18 and 80 years
- Able to sit in a knee extension machine
- Able to deliver muscle biopsies
- Able to train 3 times per week during a 6-week period
- Inclusion Criteria - heart failure patients
- Chronic congestive ischemic heart failure
- LV ejection fraction ≤45%
- NYHA function class II-IV
- Inclusion Criteria - healthy subjects
- • See general criteria for inclusion
- Exclusion Criteria - healthy subjects
- Myocardial infarction
- Angina pectoris
Exclusion
- Pregnancy
- Diabetes mellitus
- Peripheral neuropathy
- Dialysis treatment
- Severe peripheral arterial disease
- Concomitant acute life threatening medical condition
- Medications known to modify the effect of ischemic conditioning such as cyclosporin and glibenclamide.
- Recent cardiovascular hospitalization (within last 30 days)
- Intracranial aneurisms, arteriovenous malformation, cerebral neoplasm or abscess.
- Myocardial infarction
- Angina pectoris
- Severe arterial hypertension (≥ 180/≥ 110 mmHg) or moderate arterial hypertension (160-179/100-109) despite medical treatment.
- Moderate to severe cardiac valve disease
- Beta blocker medication
- Moderate or severe chronic obstructive pulmonary disease
- Decreased kidney function - eGFR \< 60 ml/min.
- Criteria for stopping the intervention or investigations
- Severe discomfort and/or by request of the participant.
- Safety considerations as assessed by the investigator.
- Withdrawal of informed consent.
- Not able to fulfill the protocol.
Key Trial Info
Start Date :
September 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 1 2019
Estimated Enrollment :
84 Patients enrolled
Trial Details
Trial ID
NCT03380663
Start Date
September 1 2016
End Date
July 1 2019
Last Update
December 22 2017
Active Locations (1)
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1
Aarhus University
Aarhus, Denmark, 8000