Status:
WITHDRAWN
Phase I Study of Biweekly SIRB Regimen for Metastatic Colorectal Cancer
Lead Sponsor:
Fujian Cancer Hospital
Conditions:
Metastatic Colorectal Cancer
Eligibility:
All Genders
20-75 years
Phase:
PHASE1
Brief Summary
Phase I Study of biweekly combination therapy with S-1, Irinotecan, and Bevacizumab as 1-line Chemotherapy in Patients With Advanced Colorectal Cancer.
Detailed Description
In several clinical studies from Japan and South Korea, the combination regimen of S-1 and irinotecan has shown efficacy in the treatment of advanced colorectal cancer, and a Phase III study（TRICOLORE...
Eligibility Criteria
Inclusion
- Histologically confirmed colorectal carcinoma with inoperable, locally advanced, or metastatic disease, not amenable to curative therapy
- Measurable disease or non-measurable but assessable disease according to the Response Evaluation Criteria in Solid Tumors (RECIST)
- Patients with no previous treatment (radiotherapy or chemotherapy). Patients who have received postoperative adjuvant chemotherapy are eligible if relapse is diagnosed more than 180 days after the end of such treatment.
- Age ≥20 years
- Life expectancy of at least 3 months
- ECOG PS of 0 or 1
- Adequate function of major organs as defined below:
- Hemoglobin ≥9.0g/dL
- White blood cell count ≥3,500/mm3
- Neutrophil count ≥1,500/mm3
- Platelet count ≥100,000/mm3
- AST and ALT ≤100 U/L (\<200 U/L in patients with liver metastasis)
- Serum creatinine ≤1.2 mg/dL
- Creatinine clearance estimate by the Cockcroft-Gault method \>50 mL/min (reduce initial dosage by one step if ≥50 but \<80 mL/min)
- Able to take capsules orally.
- No electrocardiographic abnormalities within 28 days before enrollment that would clinically preclude the execution of the study, as judged by the investigator.
- Voluntary written informed consent.
Exclusion
- Serious drug hypersensitivity or a history of drug allergy
- Active double cancer
- Active infections (e.g., patients with pyrexia of 38℃ or higher)
- History of gastrointestinal perforation, intestinal tract paralysis, or ileus within 1 year.
- Uncontrolled hypertension
- Serious complications (e.g., pulmonary fibrosis, interstitial pneumonitis, heart failure, renal failure, hepatic failure, or poorly controlled diabetes)
- Moderate or severe ascites or pleural effusion requiring treatment
- Watery diarrhea
- Treatment with flucytosine or atazanavir sulfate
- Metastasis to the CNS
- Pregnant women, possibly pregnant women, women wishing to become pregnant, and nursing mothers. Men who are currently attempting to conceive children.
- Severe mental disorder
- Continuous treatment with steroids
- Urine dipstick for proteinuria should be \<2+
- Patient with a past history of thrombosis, cerebral infarction, myocardial infarction, or pulmonary embolism
- Major surgical procedure, open biopsy, or clinically significant traumatic injury within 4 weeks
- Long-term daily treatment with aspirin (\>325 mg/day)
- History or evidence of inherited bleeding diathesis or coagulopathy with the risk of bleeding
- Judged ineligible for participation in the study by the investigator for safety reasons.
Key Trial Info
Start Date :
January 5 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 5 2019
Estimated Enrollment :
Patients enrolled
Trial Details
Trial ID
NCT03380689
Start Date
January 5 2018
End Date
January 5 2019
Last Update
March 8 2021
Active Locations (1)
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1
Rongbo Lin
Fuzhou, Fujian, China, 350014