Status:
UNKNOWN
CTC, Free DNA, Stem Cells and EMT-related Antigens as Biomarkers of Activity of Cabazitaxel in CRPC.
Lead Sponsor:
Istituto Romagnolo per lo Studio dei Tumori Dino Amadori IRST S.r.l. IRCCS
Conditions:
Prostate Cancer
Metastatic Cancer
Eligibility:
MALE
18+ years
Brief Summary
Identification of biomarkers (Circulating Tumor Cells (CTC), free DNA, Stem Cells and EMT-related antigens) that may be predictive of outcome of activity of cabazitaxel treatment in castration-resista...
Detailed Description
Circulating Tumor Cells, free DNA, Stem Cells and EMT-related antigens as biomarkers of activity of cabazitaxel in castration-resistant prostate cancer Primary objectives: To evaluate the prognostic ...
Eligibility Criteria
Inclusion
- Ability to understand and the willingness to sign a written informed consent document
- Male aged \>18 years with metastatic castration-resistant disease with documented clinical (imaging) and/or biochemical progression (PSA increasing values) during or after a previous docetaxel-based chemotherapy
- Patients must have metastatic and/or inoperable disease
- Patients must have received prior therapy docetaxel based and must be candidate to cabazitaxel
- Life expectancy of greater than 3 months
- Eastern Cooperative Oncology Group (ECOG) performance status \<2
Exclusion
- Participants who are unable to provide informed consent
- Participation in another clinical trial
Key Trial Info
Start Date :
December 15 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
December 1 2023
Estimated Enrollment :
104 Patients enrolled
Trial Details
Trial ID
NCT03381326
Start Date
December 15 2014
End Date
December 1 2023
Last Update
June 2 2023
Active Locations (9)
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1
Ospedali Riuniti Umberto I
Ancona, AN, Italy
2
Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (IRST)
Meldola, FC, Italy, 47014
3
IRCCS AOU San martino IST
Genova, GE, Italy, 16132
4
Ospedale Civile degli Infermi
Rimini, RN, Italy