Status:
RECRUITING
International PPB/DICER1 Registry
Lead Sponsor:
Children's Hospitals and Clinics of Minnesota
Collaborating Sponsors:
Washington University School of Medicine
ResourcePath, LLC
Conditions:
Pleuropulmonary Blastoma
Sertoli-Leydig Cell Tumor
Eligibility:
All Genders
Up to 100 years
Brief Summary
Pleuropulmonary blastoma (PPB) is a rare malignant neoplasm of the lung presenting in early childhood. Type I PPB is a purely cystic lesion, Type II is a partially cystic, partially solid tumor, Type ...
Detailed Description
PPB is a rare cancer of the lung presenting in early childhood, mostly commonly from birth to age \~72 months. PPB occurs within the lung or between the lung and the chest wall. There are three primar...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Known or suspected PPB or related thoracic tumor
- Known or suspected sex-cord stromal tumor including Sertoli-Leydig cell tumor and gynandroblastoma (males or females)
- Other known or suspected DICER1-related condition including ovarian sarcoma, cystic nephroma, renal sarcoma, pineoblastoma, pituitary blastoma, nasal chondromesenchymal hamartoma, ciliary body medulloepithelioma and others
- Individuals with known or suspected DICER1 pathogenic variation regardless of whether they have an established DICER1-associated condition
- Informed consent by patient/ or parent/guardian (also, where appropriate: assent and HIPAA consent)
- Exclusion criteria:
- Absence of appropriate consent for Registry participation
Exclusion
Key Trial Info
Start Date :
December 6 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 6 2035
Estimated Enrollment :
3400 Patients enrolled
Trial Details
Trial ID
NCT03382158
Start Date
December 6 2016
End Date
December 6 2035
Last Update
January 30 2025
Active Locations (1)
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1
Children's Minnesota
Minneapolis, Minnesota, United States, 55404