Status:
RECRUITING
Effect of Dexmedetomidine on the Minimum Alveolar Concentration of Sevoflurane
Lead Sponsor:
Baylor College of Medicine
Conditions:
Pediatric Anesthesia
Eligibility:
All Genders
1-36 years
Phase:
PHASE4
Brief Summary
The purpose of this protocol is to determine the effect of two clinically applicable Dexmedetomidine dosages (0.5mcg/kg and 1mcg/kg) on the minimum alveolar concentration (MAC) of Sevoflurane in child...
Detailed Description
The anesthetic potency of an inhalational anesthetic is measured by the minimum alveolar concentration (MAC), or the dose required to suppress movement to a surgical stimulus in 50% of patients. This ...
Eligibility Criteria
Inclusion
- Exclusion Criteria:
- Interstitial lung disease, chest wall disease, or bronchospastic disease with no flare-ups in the past 2 weeks of presentation
- History of difficult intubation or ventilation
- Airway malformation
- Congenital heart disease
- Cardiac arrhythmias
- Central nervous system disease, including developmental delay, cerebral palsy, or seizure disorder
- History of or family history of malignant hyperthermia
- Electrolyte disorders
- Gastrointestinal disease
- Hepatic dysfunction
- Renal dysfunction
- Metabolic disease, such as diabetes
- Obesity, defined as a body mass index greater than the 95% percentile for age
- Preterm infant (less than 37 weeks gestational age) 15. Use of any medications (anticonvulsants, opioids, benzodiazepines, antibiotics, antihistamines drugs that induce hepatic enzymes) that may affect MAC.
- Inclusion Criteria
- All patients age 1 month- 3 years presenting for surgery.
Exclusion
Key Trial Info
Start Date :
February 18 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
180 Patients enrolled
Trial Details
Trial ID
NCT03384563
Start Date
February 18 2018
End Date
December 31 2025
Last Update
September 22 2025
Active Locations (1)
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1
Texas Children's Hospital
Houston, Texas, United States, 77030