Status:
UNKNOWN
Gut Mucosal Microbiota is Associated With Colorectal Cancer Relapse
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University
Conditions:
Gut Microbiota
Colorectal Cancer
Eligibility:
All Genders
35-80 years
Brief Summary
Colonic microbiome has been found to contribute to the development of colorectal cancer. We speculate that gut microbiota related to colorectal cancer relapse after curative treatment. This study aim ...
Detailed Description
Treatments for colorectal cancer of all stages have evolved considerably over the past two decades, resulting in improved long-term outcomes. After curative treatment, however, 30% of patients with st...
Eligibility Criteria
Inclusion
- Requirements of informed consent and assent of participant, parent or legal guardian as applicable
- Patients with colorectal cancer scheduled for radical coloproctectomy and between the age of 18 and 75 years old without considering sex.
- Patients with BMI= 18.5-23.9
- Participants can follow the visit plan
Exclusion
- Patients with colorectal cancer with distant metastasis
- Chronic renal diseases and hepatic cirrhosis
- Chronic ischemic heart disease with unstable angina, chronic heart failure at class III or IV and acute myocardial infarction in the last 6 months
- Individuals with a history of Chronic diarrhea
- Individuals with a history of Diabetes mellitus
- Individuals with a history of Hypertension
- Individuals with a history of autoimmune diseases
- Use of antibiotics and probiotics 3 mouth before samples collection
- Individuals with a history of abdominal operation due to any reason
- Individuals with any history of cancer other than colorectal cancer
- Individuals with Inflammatory bowel disease
Key Trial Info
Start Date :
May 1 2016
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2022
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03385213
Start Date
May 1 2016
End Date
December 1 2022
Last Update
May 9 2018
Active Locations (1)
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1
Yunwei Wei
Harbin, Heilongjiang, China, 150001