Status:
COMPLETED
Effects of Different Stimuli in Patients With Disorders of Consciousness
Lead Sponsor:
First Affiliated Hospital of Zhejiang University
Conditions:
Disorder of Consciousness
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
In recent years, promoting wakening attempts in patients with disorders of consciousness are increasing, but there are a lack of objective indicators to evaluate the efficacy and further researches on...
Detailed Description
Auditory stimuli have potential beneficial effects on cognitive functions and consciousness in patients with disorders of consciousness (DOC)，especially the emotional sound; however, precise and accur...
Eligibility Criteria
Inclusion
- Brain-damaged patients :
- Disorders of consciousness (Traumatic brain injury, stroke or anoxic encephalopathy)
- Coma diagnosis (Plum and Posner, 1966), vegetative state (Task Force, 1994) or minimally conscious state (Giacino, Ashwal et al. 2002)
- Lack of autonomic crisis since one week minimum
- Medical condition considered stable
- Patients who do not present hearing loss. Peaks I and II of Brainstem Auditory Evoked Potentials (BAEP) will be normal.
Exclusion
- hearing Problem
- Uncontrolled Epilepsy
- Autonomic crises
- Medical unstable state
- Pregnant or likely to be (interrogation data) or breastfeeding woman
- Healthy participants :
- Inclusion Criteria:
- Subjects with normal hearing
- Absence of neurological disorder
- Subjects able to understand the experimental instructions
Key Trial Info
Start Date :
July 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 30 2017
Estimated Enrollment :
28 Patients enrolled
Trial Details
Trial ID
NCT03385291
Start Date
July 1 2015
End Date
July 30 2017
Last Update
March 8 2018
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