Status:
COMPLETED
Intergenerational Programming of Diabesity in Offspring of Women With Gestational Diabetes Mellitus
Lead Sponsor:
Kem Hospital, Pune, India
Collaborating Sponsors:
Centre for Cellular and Molecular Biology, Hyderabad, India
Conditions:
Gestational Diabetes
Eligibility:
All Genders
Brief Summary
India is one of the diabetes capitals in the world. Indians are susceptible to develop diabetes at a younger age and at a lower BMI compared to Europeans. Current prevention strategies focus on reduci...
Detailed Description
The DOHaD paradigm proposes that early life nutrition and growth influence health and disease risk across the life-course. Intrauterine period is the most crucial period in these events, and contribut...
Eligibility Criteria
Inclusion
- Arm 1 and 2:
- GDM or NGT on 75g OGTT (IADPSG Criteria).
- Willing to participate and sign consent
- Planned delivery at study site
- Age \> 18 years
- Singleton pregnancy.
- Arm 3:
- 1\. Offspring of diabetic mothers and non diabetic mothers ( \>2 years of age).
Exclusion
- Arm 1 and 2:
- Severe medical/ surgical illness detrimental to pregnancy or delivery (Severe liver, renal, cardiovascular, pulmonary, hematologic, endocrine disorder or long term steroid use for any reason)
- K/C/O Diabetes (Type 1 or Type 2 or any other type)
- Severe anemia (Hemoglobin\< 9 gm% in first trimester and \< 8 gm% in second or third trimester)
- IVF pregnancy.
- Arm 3: None.
Key Trial Info
Start Date :
September 2 2014
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
November 30 2018
Estimated Enrollment :
1178 Patients enrolled
Trial Details
Trial ID
NCT03388723
Start Date
September 2 2014
End Date
November 30 2018
Last Update
April 1 2019
Active Locations (1)
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1
KEM Hospital
Pune, Maharashtra, India, 411011