Status:
UNKNOWN
Gut Microbiota is Associated With Autoimmune Thyroid Disease
Lead Sponsor:
First Affiliated Hospital of Harbin Medical University
Conditions:
Gut Microbiota
Eligibility:
All Genders
18-65 years
Brief Summary
Autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Grave's disease (GD), are the most common organ-specific autoimmune diseases and affect more women than men, with a f...
Detailed Description
Autoimmune thyroid disease (AITD), which includes Hashimoto's thyroiditis (HT) and Grave's disease (GD), are the most common organ-specific autoimmune diseases and affect more women than men, with a f...
Eligibility Criteria
Inclusion
- Aged 18 to 65 years
- Male or female gender
- Euthyroidism (normal FT3, FT4, and TSH plasma levels without hormonal therapy)
Exclusion
- Pregnancy
- Lactation
- Cigarette smoking
- Alcohol addiction
- Hypertension
- Diabetes mellitus
- Lipid dysregulation
- BMI \> 27
- Recent (\< 3 months prior) use of antibiotics, probiotics, prebiotics, symbiotics, hormonal medication, proton pump inhibitors, insulin sensitizers or Chinese herbal medicine
- Known history of disease with an autoimmune component such as MS, rheumatoid arthritis, IBS, and IBD
- History of malignancy or any gastrointestinal tract surgery (e.g., gastrectomy, bariatric surgery, colectomy, ileectomy, cholecystectomy or appendectomy).
Key Trial Info
Start Date :
April 20 2017
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
November 1 2021
Estimated Enrollment :
200 Patients enrolled
Trial Details
Trial ID
NCT03390582
Start Date
April 20 2017
End Date
November 1 2021
Last Update
January 4 2018
Active Locations (1)
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1
First affiliated hospital of Harbin medical university
Harbin, Heilongjiang, China, 150001