Status:
UNKNOWN
Dexmedetomidine and Swallowing Function
Lead Sponsor:
Region Örebro County
Conditions:
Deglutition
Eligibility:
All Genders
18-40 years
Phase:
PHASE4
Brief Summary
The purpose of the study is to evaluate the impact of dexmedetomidine on swallowing function in healthy volunteers using combined pressure and impedance recordings. Furthermore, two different concentr...
Detailed Description
Monitored anesthesia care (MAC) is commonly applied in modern perioperative care and means that minor surgical procedures are accomplished in awake patients using local anesthesia and light sedation. ...
Eligibility Criteria
Inclusion
- ≥ 18 - ≤ 40 year old healthy volunteers from both sexes.
- Have signed and dated Informed Consent.
- Willing and able to comply with the protocol for the duration of the trial.
Exclusion
- Anamnesis of pharyngoesophageal dysfunction.
- Known or history of gastrointestinal, severe cardiac, pulmonary or neurological disease
- Ongoing medication that may affect upper gastrointestinal tract, larynx or lower airway.
- Allergies to or history of reaction to remifentanil, fentanyl analogues or dexmedetomidine.
- Known heart rhythm disorder.
- Tendency to faint.
- Pregnancy or breast feeding
- BMI \> 30
- Smoking
- Participation in a medicinal clinical trial during the last year where an opioid has been used or have during the last 30 days participated in any other medicinal clinical trial or in a trial where follow-up is not completed.
Key Trial Info
Start Date :
January 22 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 11 2018
Estimated Enrollment :
20 Patients enrolled
Trial Details
Trial ID
NCT03390972
Start Date
January 22 2018
End Date
April 11 2018
Last Update
January 5 2018
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