Status:
COMPLETED
Multiomics and Imaging-based Assessment of Vulnerable Coronary Plaques in Acute Coronary Syndromes
Lead Sponsor:
Cardio Med Medical Center
Conditions:
Coronary Stenosis
Acute Coronary Syndrome
Eligibility:
All Genders
18+ years
Brief Summary
The aim of Multiplaque clinical study is to assess the vulnerability degree of the atheromatous plaques, before and after a myocardial infarction (MI), based on multiomics analysis, associated with in...
Detailed Description
This is a prospective cohort monocentric study. The primary objective of this study is to research the vulnerability degree of ateromatous plaques before and after a myocardial infarction, based on m...
Eligibility Criteria
Inclusion
- Substudy 1:
- Patients aged at least 18 years
- Patients who have signed the informed consent
- Unstable angina type acute coronary syndrome with maximum 48h before presentation, defined as the presence of typical angina pain, with duration of more than 5 minute, accompanied by ECG changes.
- Substudy 2:
- Patients aged at least 18 years
- Patients who have signed the informed consent
- Acute myocardial infarction (STEMI or NSTEMI) defined as typical changes on the ECG (ST elevation of minimum 1 mm in at least 2 consecutive leads - STEMI; ST-T changes for NSTEMI) accompanied by increased levels of cardiac troponin I or T, or CK-MB of more than 2x the normal reference value of the laboratory.
Exclusion
- (for both substudies)
- Known sensibility for the contrast agents
- Women at reproductive age who does not use contraceptive methods
- Pregnant women
- Any malignancy within the last 5 years
- Acute or chronic renal failure
- Any disease or comorbidity that reduces the life expectancy under 2 years
- Non-compliant patients who, in the opinion of the investigators, will not undergo the follow-up process
Key Trial Info
Start Date :
April 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 31 2021
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT03391908
Start Date
April 1 2018
End Date
January 31 2021
Last Update
August 2 2022
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
Cardio Med SRL
Târgu Mureş, Mureș County, Romania, 540136