Status:
UNKNOWN
Perioperative Research Into Memory, Genomics in the Intensive Therapy Unit: Alzheimer's
Lead Sponsor:
Chelsea and Westminster NHS Foundation Trust
Conditions:
Cognitive Impairment
Apolipoprotein E, Deficiency or Defect of
Eligibility:
All Genders
18-25 years
Brief Summary
The current central dogma of long-term cognitive impairment after intensive care admission suggests an underlying neuroinflammatory dysregulation affecting neuronal function. This pathological process...
Detailed Description
Long-lasting post-operative cognitive dysfunction (POCD) is now a well-recognised complication of surgery, anaesthesia and critical care. It has been shown that cognitive impairment in critical care s...
Eligibility Criteria
Inclusion
- Consenting individual
- Burn injury \>15% total body surface area
- Admission to a Burns Intensive Care Unit between Jan 2007- Jan 2012
- Intubated and ventilated during the admission
Exclusion
- Patients admitted to BICU with Toxic Epidermal Necrolysis Syndrome or Steven-Johnson Syndrome
- Head trauma
- Currently held under the 2007 Mental Health Act (UK) or Section 5150 of the California Welfare and Institutions Code (USA).
- Currently receiving formal psychiatric treatment (including involvement in a Personality Disorder Unit, being under voluntary section, current re-occurrence of chronic self-harm)
- Current imprisonment
- Current substance abuse (within two weeks of assessment)
- Patients unable to understand plain verbal and written English.
Key Trial Info
Start Date :
February 1 2018
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2019
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03393130
Start Date
February 1 2018
End Date
December 1 2019
Last Update
January 8 2018
Active Locations (0)
Enter a location and click search to find clinical trials sorted by distance.
No Results Found
We couldn’t find results for the location/zipcode entered or within the selected range. Please check your input or adjust your search.