Status:
COMPLETED
Effects of Methylprednisolone on Immunological Function and Postoperative Pain
Lead Sponsor:
Shengjing Hospital
Conditions:
Methylprednisolone
Immunological Function
Eligibility:
All Genders
65-85 years
Phase:
PHASE4
Brief Summary
Surgical trauma is characterized by a tightly integrated sequence of neurohumoral and immunological processes. When this is marked, it can manifest as a clinical entity called the systemic inflammator...
Detailed Description
The eighty-one patients were randomly assigned either to the MP Group or the Control Group in a 1:1 ratio using a computer-generated randomization number sequence. The group assignment was sealed in s...
Eligibility Criteria
Inclusion
- ASA Ⅱ～Ⅲ
- aged 65-85years
- consciousness,with no psychological or communication disorders, with educational level above primary school (including primary school).
- with no chemotherapy or radiotherapy before admission.
- no history of medicine allergy.
- no evident abnormality of liver, kidney or nervous system
- scheduled for radical operation for lung cancer under general anesthesia
Exclusion
- diagnosed with diseases in nervous system or psychological disorder, history of taking sedatives or anti-depressants.
- history of hypertension, diabetes, coronary heart disease, cerebral infarction.
- had drugs which affect immunological function before.
- severe acuity or vision dysfunction or have difficulty in communication.
- with special complications during surgery.
- had blood transfusion treatment during perioperation period history of heart operation
- Mini-mental State Examination Scores less than 25 before surgery.
Key Trial Info
Start Date :
July 1 2015
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
January 15 2017
Estimated Enrollment :
112 Patients enrolled
Trial Details
Trial ID
NCT03393949
Start Date
July 1 2015
End Date
January 15 2017
Last Update
December 10 2020
Active Locations (1)
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1
Shengjing hospital of China medical university
Shenyang, Liaoning, China, 110000