Status:
COMPLETED
The Optimal Time of IV Dexamethasone Administration for Prolongation of Peripheral Nerve Block
Lead Sponsor:
University Health Network, Toronto
Conditions:
Peripheral Nerve Block Prolongation
Hand Injury Wrist
Eligibility:
All Genders
18-80 years
Phase:
PHASE4
Brief Summary
The purpose of this study is to determine the optimal timing of IV dexamethasone for prolongation of ultrasound (US) guided supraclavicular brachial plexus block (SCB) in patients undergoing unilatera...
Detailed Description
This is a prospective double-blind randomized trial to evaluate the optimal timing of IV dexamethasone. All patients undergoing isolated hand or forearm surgery under anesthetic will be approached to ...
Eligibility Criteria
Inclusion
- Patients having isolated hand or forearm surgery under anesthetic ultrasound - guided SCB
- ASA class I - III
- Age 18 - 80 years, inclusive
- BMI \<35
Exclusion
- Pre - existing neuropathy or neurological deficit in the distribution of the nerves to be anaesthetized
- Contra-indication to regional anesthesia / supraclavicular brachial plexus blockade; bleeding diathesis, coagulopathy, local infection, severe respiratory disease
- Anatomical deformity precluding block placement
- Patients with a known history of hypersensitivity to local anesthetics and / or dexamethasone
- Patients taking steroid therapy
- Positive pregnancy test
- Inability to give informed consent
- Anticipated surgical time \< 30 or \> 180 minutes
- Any known contraindication for IV dexamethasone as per the product monograph:bacteremia and systemic fungal infections, hypersensitivity to any of the products components, gastric and duodenal ulcers, certain viral infections (i.e. varicella \& herpes genitalis)
Key Trial Info
Start Date :
May 30 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 16 2024
Estimated Enrollment :
197 Patients enrolled
Trial Details
Trial ID
NCT03394820
Start Date
May 30 2017
End Date
February 16 2024
Last Update
July 17 2024
Active Locations (1)
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1
Toronto Western Hopspital
Toronto, Ontario, Canada, M5T2S8