Status:
COMPLETED
Myeloid Cell Reprogramming in Thyroid Carcinoma
Lead Sponsor:
Radboud University Medical Center
Conditions:
Thyroid Cancer
Eligibility:
All Genders
18+ years
Brief Summary
This study investigates the reprogramming of myeloid cells in patients with thyroid carcinoma. The investigators hypothesize that tumor-derived factors change the function of myeloid cells (peripheral...
Detailed Description
Description of the problem: Non-medullary thyroid carcinoma (TC) is the most common endocrine malignancy and its incidence is one of the most rapidly increasing among the cancer types. For many patie...
Eligibility Criteria
Inclusion
- Group 1:
- Subject is newly diagnosed with TC, therapy-naive and is planned to receive conventional treatment by surgery followed by RAI; no evidence of local or distant metastases
- Group 2:
- Subject has TC with evidence of distant metastases (either newly diagnosed or therapy-naive or patients with persistent or recurrent disease); at least 4 months since the previous treatment with RAI if applicable
- Group 3:
- Subject is diagnosed with MNG, is euthyroid, and is planned to undergo surgery - Group 4: Subject is diagnosed with MNG, is euthyroid, and is planned to receive RAI treatment
- \- Group 5: Healthy individuals who are euthyroid and have no evidence of thyroid disease
Exclusion
- Mentally incompetent
- Pregnant, trying to become pregnant or breastfeeding
- Known inflammatory or infectious diseases or an immunosuppressive status
- Using medication interfering with the immune system
- Reduced platelet counts or other conditions associated with an increased risk of bleeding
- Severe comorbidities: other active malignancy (except for basal cell carcinoma)
- Serious psychiatric pathology
- A self-reported alcohol consumption of \>21 units per week
Key Trial Info
Start Date :
March 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 5 2021
Estimated Enrollment :
41 Patients enrolled
Trial Details
Trial ID
NCT03397238
Start Date
March 6 2018
End Date
January 5 2021
Last Update
February 9 2022
Active Locations (1)
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1
Radboudumc
Nijmegen, Netherlands, 6525GA