Status:
COMPLETED
Quantification of Nerve Stiffness in Neuropathies
Lead Sponsor:
Nantes University Hospital
Collaborating Sponsors:
Université de Nantes
Conditions:
Chronic Inflammatory Demyelinating Polyneuropathy
Charcot-Marie-Tooth Disease, Type IA
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This project aims to understand how nerve mechanical properties are altered in patients with rare peripheral neuropathies . Stiffness of various peripheral nerves will be measured using ultrasound she...
Detailed Description
The following nerve will be studied bilaterally, in a randomised order: Median, ulnar, Radial, Sciatic and Tibial. Participants will be asked to remain relaxed during elastography measurements.
Eligibility Criteria
Inclusion
- Male or female aged 18 to 65
- Having social insurance status
- Having given informed consent
- Diagnostic of chronic inflammatory demyelinating polyradiculoneuropathy (CIDP), CMT1a or Anti-MAG (peak immunoglobulin M (IGm)\>15,000 BTU)
Exclusion
- For controls:
- Person staying in a health or social facility
- Person unable to understand the protocol and to respect the modalities
- Person deprived of liberty
- Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- Participation in another biomedical research in progress
- Diabetes, history of neuromuscular disease
- For CIDP:
- Person staying in a health or social facility
- Person unable to understand the protocol and to respect the modalities
- Person deprived of liberty
- Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- Participation in another biomedical research in progress
- MRC score \< 3
- For Charcot-Marie-Tooth type 1 (CMT1) and anti-MAG:
- Person staying in a health or social facility
- Person unable to understand the protocol and to respect the modalities
- Person deprived of liberty
- Person of legal age benefiting from a system of legal protection (guardianship, curators or safeguard of justice)
- Participation in another biomedical research in progress
Key Trial Info
Start Date :
April 11 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 8 2023
Estimated Enrollment :
36 Patients enrolled
Trial Details
Trial ID
NCT03397303
Start Date
April 11 2018
End Date
December 8 2023
Last Update
January 27 2025
Active Locations (1)
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1
Univeristy of Nantes
Nantes, France, 44093