Status:
ENROLLING_BY_INVITATION
Defining the Temporal Changes in the Acute Phase Response During Graded Exercise: A Prospective Study
Lead Sponsor:
Vanderbilt University Medical Center
Conditions:
Acute Phase Response
Eligibility:
All Genders
18-49 years
Phase:
NA
Brief Summary
The purpose of this study is to detail the precise temporal changes in the APR that occur in response to exercise in order to determine the types of exercise that confer maximal reparative fibrinolysi...
Detailed Description
Injury, ranging from a paper cut that barely splits the skin to a high-speed motor vehicle accident that rips through muscle and bone, causes a disruption of tissue compartments. This breach of compar...
Eligibility Criteria
Inclusion
- Arm 1: 20-minute graded exercise Inclusion criteria
- Healthy individuals (male or female) aged 18-29
- Regular participation (at least 2 times per week) in moderate intensity exercise
- BMI between 18.5 and 30.0
- Exclusion criteria
- Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
- Acute disease process such as an infection, broken bone, or asthma attack
- Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
- Pregnant women
- Recent inpatient admission within the last six months
- History of smoking or illicit drug use
- Arm 2: Marathon participation Inclusion criteria
- Healthy individuals (male or female) aged 18-49
- In training to complete a marathon (individuals already planning on running a marathon and training accordingly for it)
- BMI between 18.5 and 30.0
- Exclusion criteria
- Pre-existing health conditions or injuries that may limit the ability to safely participate in exercise
- Acute disease process such as an infection, broken bone, or asthma attack
- Chronic or recent use (within the last 10 days) of any anticoagulant medication or NSAID
- Pregnant women
- Recent inpatient admission within the last six months
- History of smoking or illicit drug use
Exclusion
Key Trial Info
Start Date :
November 29 2017
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
35 Patients enrolled
Trial Details
Trial ID
NCT03398304
Start Date
November 29 2017
End Date
April 1 2027
Last Update
April 2 2025
Active Locations (1)
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1
Vanderbilt Orthopaedics
Nashville, Tennessee, United States, 37232