Status:
COMPLETED
Sperm Selection by Either PICSI or MACS in Cases With Abnormal Sperm DNA Fragmentation Index for ICSI
Lead Sponsor:
Ganin Fertility Center
Collaborating Sponsors:
The Cleveland Clinic
University of the Western Cape
Conditions:
Sperm DNA Fragmentation
Eligibility:
All Genders
18-40 years
Phase:
NA
Brief Summary
On the day of ICSI, choosing the best sperm by either PICSI or magnetic activated cell sorting (MACS) in cases with abnormal DNA is not fully investigated. This study helps in solving this problem by ...
Detailed Description
Sperm DNA fragmentation has shown a negative correlation with fertilization rate, embryo quality, and implantation rate. And a positive correlation with miscarriage rate in the 1st trimester. Sperm s...
Eligibility Criteria
Inclusion
- Males diagnosed of abnormal DNA fragmentation index ( \> 19%).
- Males with mild to moderate OTA (oligoteratoasthenozoospermia).
- Male aged 18-60 years.
- Female aged 18-40 years.
- Normo responder ( \> 5 mature oocytes)
- Male will have to refrain from ejaculation no less than 1 day but no greater than 3 days prior semen specimen production on day of oocyte retrieval
Exclusion
- Males with normalDNA fragmentation index (\<19%)at the initial assessment.
- Leukocytospermia
- Presence of varicocele.
- Known genetic abnormality
- Use of sperm donation or cryopreserved sperm
- Use of Oocyte donation
- Use of gestational carrier
- Presence of any of the endometrial factors that affect embryo implantation such as hydrosalpings, adenomyosis or previous uterine infection
- Any contradictions to undergoing in vitro fertilization or gonadotropin stimulation
Key Trial Info
Start Date :
January 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2019
Estimated Enrollment :
396 Patients enrolled
Trial Details
Trial ID
NCT03398317
Start Date
January 1 2017
End Date
March 30 2019
Last Update
July 21 2020
Active Locations (1)
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1
Ganin Fertility Center
Cairo, Egypt