Status:
COMPLETED
Broccoli Supplement Dose Response
Lead Sponsor:
Johns Hopkins Bloomberg School of Public Health
Collaborating Sponsors:
Qidong Liver Cancer Institute
Conditions:
Healthy Volunteers
Eligibility:
All Genders
21-70 years
Phase:
NA
Brief Summary
Do daily high (4 tablets) or intermediate (2 tablets) administration of the broccoli-based dietary supplement Avmacol® have improved bioavailability over a broccoli sprout beverage rich in sulforaphan...
Detailed Description
The investigators will conduct a 3-armed placebo-controlled 16-day intervention with the dietary supplement Avmacol® to determine the bioavailability with repeated dosing of a simple tablet-based inte...
Eligibility Criteria
Inclusion
- Age ≥ 21 and ≤ 70 years who are residents of Qidong, China.
- Able to provide written, informed consent.
- Normal physical examination and medical history indicative of good general health with no history of chronic illness.
- No hepatomegaly by clinical exam;
- Normal liver function tests (ALT, aspartate aminotransferase (AST), bilirubin);
- Normal renal function tests (creatinine, blood urea nitrogen (BUN), urinalysis);
- Serum alpha-fetoprotein (AFP) negative.
Exclusion
- Pregnant (positive human chorionic gonadotropin (HCG) strip test)
- Current or former diagnosis of cancer, with the exception of non-melanomatous skin cancer.
Key Trial Info
Start Date :
January 10 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 15 2018
Estimated Enrollment :
170 Patients enrolled
Trial Details
Trial ID
NCT03399656
Start Date
January 10 2018
End Date
February 15 2018
Last Update
October 4 2022
Active Locations (1)
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1
Qidong Liver Cancer Institute
Qidong, Jiangsu, China, 226200