Status:
COMPLETED
Pharmacokinetics and Tolerability of Sulthiame
Lead Sponsor:
Centre Hospitalier Universitaire Vaudois
Collaborating Sponsors:
Advicenne Pharma
Conditions:
Epilepsy
Eligibility:
MALE
18-45 years
Phase:
PHASE1
Brief Summary
This preliminary pilot exploration aims at specifying the pharmacokinetic parameters of sulthiame, formulated as an immediate release tablet, thus helping to design proper clinical trials for the futu...
Detailed Description
Sulthiame (or sultiame), marketed in the 60's in Germany, Austria, Switzerland, Israel, Australia and Japan under the brand name Ospolot®, has progressively become the therapeutic first choice in beni...
Eligibility Criteria
Inclusion
- Healthy male subjects aged between 18 and 45 years.
- Body weight (BW) ranging between 55 and 95 kg, providing body mass index (BMI) is between 18 and 29 kg/m2
- Absence of significant findings in the medical history and physical examination as judged by the Investigator, especially for cardiovascular, pulmonary, haematological and nervous systems
- Absence of significant laboratory abnormalities as judged by the Investigator. Gilbert's syndrome (increased total and unconjugated bilirubin when fasting) will be accepted if mild
- Absence of clinically significant abnormalities on 12-lead electrocardiogram (ECG)
- Negative urine drug screen (amphetamines, benzodiazepines, cannabis, cocaine, opiates)
- Commitment to refrain from travels outside Europe over the whole study duration.
- Ability to understand the procedures, agreement to participate and willingness to give written informed consent
- Co-operative attitude and availability for scheduled visits over the entire study period.
Exclusion
- History of major cardiovascular, pulmonary, hepatic, immunological, renal, haematological, gastrointestinal, genitourinary, neurological, or rheumatologic disorders
- Active diseases of any type, including inflammatory disorders and infections. Mild acne is permissible providing no systemic or local treatment is provided or planned (except for cleaning lotions)
- History of significant allergy or asthma. Allergic rhinitis or conjunctivitis is acceptable if non symptomatic when starting the study and if symptoms are not anticipated to occur during the study to a point that would require corticosteroid therapy (e.g. in case of annual use)
- History of cardiovascular dysfunction if considered as clinically relevant (conduction abnormality, arrhythmia, bradycardia, angina pectoris, cardiac hypertrophy unless elicited by training, pulmonary embolism)
- Hypertension defined as supine blood pressure \>150/90 mmHg or recurrent hypotensive events considered as clinically relevant or documented orthostatic hypotension
- Sick sinus syndrome, known long QT syndrome, reproducible observation of QTc \>440 msec or of pronounced sinus bradycardia (\<40 bpm/min)
- Intense sport activities. Moderate sport is acceptable and activities should remain fairly constant throughout the study
- Any clinically significant laboratory value on screening that are not within normal range on single repeat (Gilbert's syndrome acceptable if mild)
- Positive hepatitis B \& C antigen screen
- Positive HIV antibody screen or screen not performed
- Any recent acute illness or sequelae thereof which could expose the subject to a higher risk or might confound the results of the study
- Treatment in the previous three months with any drug known to have well-defined potential for toxicity to a major organ
- History of hypersensitivity to any drug if considered as serious including sulthiame or the excipients of the study formulation
- Use of any medication the week prior to study or as based on 5 plasma half-life rule and throughout study, including aspirin or other over-the-counter (OTC) preparation. Paracetamol is permissible before and during study as a concomitant medication but only with Investigator's permission.
- Participation in a clinical investigation or blood donation of 500 ml within the past 3 months
- History of relevant alcohol or drug abuse
- Smoking. Consumption of \<5 cigarettes/day or equivalent is acceptable providing the subject can refrain from smoking from one week before and during the whole study duration
- Consumption of a large quantity of coffee, tea, chocolate (more than 4 cups/day) or equivalent (Cola drinks)
- Present consumption of a large quantity of alcohol or wine (\>0.5 L wine/day) or equivalent, (equivalent to more than \>48 g ethanol per day).
- Project to conceive a child during the study period (by principle of precaution, while no indication exists for a definite reproductive risk following paternal exposure)
- Psychological status which could impact on subject's ability to give informed consent
- Any feature of subject's medical history or present condition which, in the Investigator's opinion, could confound the results of the study, complicate its interpretation, or represent a potential risk for the subject.
Key Trial Info
Start Date :
February 12 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2018
Estimated Enrollment :
4 Patients enrolled
Trial Details
Trial ID
NCT03400189
Start Date
February 12 2018
End Date
August 30 2018
Last Update
February 18 2020
Active Locations (1)
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1
Division of Clinical Pharmacology
Lausanne, Canton of Vaud, Switzerland, 1011