Status:
COMPLETED
Extubation Strategies in Neuro-Intensive Care Unit Patients and Associations With Outcome.
Lead Sponsor:
Nantes University Hospital
Conditions:
Brain Injuries
Eligibility:
All Genders
18+ years
Brief Summary
Rationale Prolonged mechanical ventilation (MV) is common in patients with severe Brain Injury (BI). Guidelines for the management of extubation are largely lacking for patients with BI, and the role ...
Eligibility Criteria
Inclusion
- Age ≥ 18 years' old
- Patients admitted in a ICU for a central neurological pathology, listed as follows, with estimated or clinically evaluated Glasgow Coma Score ≤12 before endo-tracheal intubation, with anomaly on brain CT-scan and requiring effective invasive mechanical ventilation ≥ 24 hours are eligible to the study:
- Traumatic Brain Injury
- Aneurysmal Subarachnoid haemorrhage
- Intra-Cranial Haemorrhage
- Ischemic Stroke
- Central Nervous System Infection (Abscess, Empyema, Meningitides, Encephalitis…)
- Brain Tumour
- Patient with an attempt of extubation and/or performance of a tracheostomy
Exclusion
- Patients \< 18 years' old
- Patients with ongoing pregnancy
- Patients with spine cord injury above T4
- Resuscitated cardiac arrest
- Withdrawal of Life-Sustaining Treatment (WLST) in the first 24 hours
Key Trial Info
Start Date :
September 6 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
January 1 2021
Estimated Enrollment :
1750 Patients enrolled
Trial Details
Trial ID
NCT03400904
Start Date
September 6 2018
End Date
January 1 2021
Last Update
April 2 2024
Active Locations (6)
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1
Nantes University Hospital
Nantes, France, 44000
2
Varanasi BHU Hospital
Varanasi, India
3
University of Genes
Genova, Italy
4
University of Amsterdam
Amsterdam, Netherlands