Status:
COMPLETED
Interest of a Vaginal Swab in Detection of Placental Alpha-Microglobulin-1 in the Prediction of Preterm Birth
Lead Sponsor:
Nantes University Hospital
Conditions:
Preterm Labor
Preterm Birth
Eligibility:
FEMALE
18+ years
Brief Summary
Preterm labor is the first cause of hospitalization during the pregnancy, and at the origin of more than 60 000 births before 37 weeks of amenorrhea every year in France. It is however difficult to pr...
Detailed Description
Preterm labor is the first cause of hospitalization during the pregnancy and complicates of a premature delivery in about 30 % of the cases during single pregnancy. It is about a clinical situation ar...
Eligibility Criteria
Inclusion
- patients presenting for emergency obstetrical care with signs suggestive of preterm labor
- single pregnancy
- gestational age between 24 + 0 and 33SA + 6 weeks of gestation
- cervical length ≤ 25mm measurement on transvaginal ultrasound with or without uterine contraction
- informed consent
- consenting to be part of the trial
Exclusion
- \< 18 years old or patient under guardianship / curators
- multiple pregnancy
- gestational term less than 24 SA or greater than or equal to 34 SA
- heavy vaginal bleeding- antecedent of conisation
- uterine malformation ( bicervical-bicorn uterus, unicervical bicorn uterus, unicorn uterus, septate uterus)
- Cervical dilatation \>3 cm.
- cervical length with transvaginal ultrasound \>25mm
- presence of a hydramnios with a superior amniotic fluid index 25
- premature rupture of manifest membranes (PROM)
- clinical or biological chorioamnionitis
- hooping cervical
- intercurrent obstetric pathology that can induce premature birth
- patient hospitalized for more than 24 hours in another hospital or service for preterm labor diagnosis
Key Trial Info
Start Date :
February 28 2018
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
February 28 2022
Estimated Enrollment :
341 Patients enrolled
Trial Details
Trial ID
NCT03401255
Start Date
February 28 2018
End Date
February 28 2022
Last Update
September 8 2022
Active Locations (2)
Enter a location and click search to find clinical trials sorted by distance.
1
La Roche-sur-yon University Hospital
La Roche-sur-Yon, France, 85191
2
Nantes University Hospital
Nantes, France, 44093