Status:
COMPLETED
Using Propranolol in Traumatic Brain Injury to Reduce Sympathetic Storm Phenomenon
Lead Sponsor:
Ain Shams University
Conditions:
Traumatic Brain Injury
Eligibility:
All Genders
18-60 years
Phase:
PHASE4
Brief Summary
Traumatic Brain Injury (TBI) is one of the leading causes of death. Severe TBT is correlated with an exaggerated stress response due to plasma catecholamine levels known as sympathetic storming. It is...
Detailed Description
The sympathetic storming events can be triggered by suctioning, repositioning, or environmental stimuli. To differentiate sympathetic storming from similar conditions, symptoms and signs have to occur...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Patients with isolated blunt TBI
- From 18 to 60 years old both sex
- Not in need of mechanical ventilation
- GCS on admission between 9 and 12
- Rotterdam CT score from 2-4.
- Normal Procalcitonin test to exclude infection.
- Exclusion criteria:
- Preexisting heart disease
- Myocardial injury
- Craniotomy
- Preexisting cerebral dysfunction
- Spinal cord injury
- Diabetes mellitus
- Severe liver or kidney disease
- Patients with sepsis
Exclusion
Key Trial Info
Start Date :
October 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 1 2017
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT03401515
Start Date
October 1 2016
End Date
August 1 2017
Last Update
January 17 2018
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