Status:
UNKNOWN
Brain and Behavioral Influences on Motor Skill Learning in Multiple Sclerosis
Lead Sponsor:
Wayne State University
Conditions:
Multiple Sclerosis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Multiple Sclerosis (MS) is characterized by episodic attacks in which there are sharp declines in physical function. Although neurorehabilitation is the most promising clinical strategy for motor reco...
Eligibility Criteria
Inclusion
- Diagnosis of Relapsing-Remitting MS,
- Patient Determined Disease Steps (PDDS) \<6.5, indicating ability to ambulate with or without an assistive device (Hohol, 1999; Learmonth, 2013)
- between the ages of 18 and 65;
- stable medication regime for 3 months prior to enrollment, and
- able to follow study-related commands.
Exclusion
- history of other neurological or neuromuscular conditions,
- acute orthopedic conditions that prevent participation in the training,
- steroid use \<30 days prior to enrollment;
- history of alcohol abuse;
- presence of metallic implants, medical implants or exposure to metallic shrapnel incompatible with MRI,
- pregnancy;
- history of hospitalization for depression; and
- depression as evidenced by a score of ≥10 on the Patient Health Questionnaire-9 (PHQ-9) (Kroenke, 2001), as depression has been shown to impact motor learning in persons with neurologic disorders (Subramanian, 2015).
Key Trial Info
Start Date :
April 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 31 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT03404388
Start Date
April 1 2020
End Date
March 31 2025
Last Update
December 12 2023
Active Locations (1)
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1
Wayne State University
Detroit, Michigan, United States, 48201