Status:
COMPLETED
IRDye800CW-BBN PET-NIRF Imaging Guiding Surgery in Patients With Lower Grade Glioma
Lead Sponsor:
Deling Li
Collaborating Sponsors:
Peking Union Medical College Hospital
National Institute for Biomedical Imaging and Bioengineering (NIBIB)
Conditions:
Glioma
Eligibility:
All Genders
18-70 years
Phase:
PHASE1
Brief Summary
This is an open-label positron emission tomography/near infrared (PET/NIRF) study to investigate the imaging navigation performance and evaluation efficacy of dual modality imaging probe 68Ga-BBN-IRDy...
Detailed Description
Lower grade gliomas (WHO grades II and III) are currently diffused disease with variability of tumor behaviors and of challenge to distinguish the margins in white-light microscope during the surgery....
Eligibility Criteria
Inclusion
- Must be able to provide a written informed consent
- suspected lower grade gliomas on contrast-enhanced MRI
Exclusion
- Consisted of conditions of mental illness
- Severe liver or kidney disease with serum creatinine \> 3.0 mg/dl (270 μΜ)
- Any hepatic enzyme level 5 times or more than normal upper limit
- Severe allergy or hypersensitivity to IV radiographic contrast
- Claustrophobia to accept the PET/CT or PET/MRI scanning
- Pregnancy or breast feeding
Key Trial Info
Start Date :
January 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 17 2018
Estimated Enrollment :
52 Patients enrolled
Trial Details
Trial ID
NCT03407781
Start Date
January 1 2016
End Date
August 17 2018
Last Update
August 6 2024
Active Locations (1)
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1
Beijing Tiantan Hospital
Beijing, China