Status:
UNKNOWN
Vancomycin Dosage Adjustment for MRSA Infections
Lead Sponsor:
Pinyo Rattanaumpawan
Conditions:
Methicillin-Resistant Staphylococcus Aureus
Eligibility:
All Genders
18+ years
Phase:
PHASE4
Brief Summary
An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods
Detailed Description
An open-label randomized controlled trial to compare two vancomycin dosage adjustment methods; a vancomycin trough concentration method and a equation-based method.
Eligibility Criteria
Inclusion
- Thai hospitalized patients, age\>18 years
- Require vancomycin therapy ≥ 3 days
- Documented MRSA infection including pneumonia, bacteremia, intra-abdominal infection or skin and soft tissue infection
- Have been checked for serum creatinine within 48 hours and serum albumin within 7 days prior to enrollment
- Received an appropriate loading dose of vancomycin
- Have been treated with an appropriate maintenance dose of vancomycin
- Willing to sign an informed consent
Exclusion
- CrCl\< 10 ml/min or receiving renal replacement therapy
- Pregnancy or lactation
- Actual BW\> 90 kg
- Serum albumin \<2 g/dl
- Having an active cancer or receiving chemotherapy
- Hx of vancomycin allergy
Key Trial Info
Start Date :
October 1 2016
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
September 1 2018
Estimated Enrollment :
114 Patients enrolled
Trial Details
Trial ID
NCT03412500
Start Date
October 1 2016
End Date
September 1 2018
Last Update
January 26 2018
Active Locations (1)
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1
Siriraj Hospital
Bangkok, Thailand, 10700