Status:
UNKNOWN
A Multi-Center Study on the Metoprolol Optimal Dosing Pathway of Metoprolol Application in Chinese Patients With Acute Coronary Syndrome
Lead Sponsor:
Yun Dai Chen
Conditions:
ACS - Acute Coronary Syndrome
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
This study is to test the feasibility and tolerability of the metoprolol optimal dosing pathway by observing the percentage of patients achieving target dose followed the pathway on ACS patients durin...
Detailed Description
Acute coronary syndrome(ACS) is one of the main manifestations of cardiovascular disease and one of the main causes for hospitalization in adults. Previous studies showed that β-receptor blockers can...
Eligibility Criteria
Inclusion
- Aged 18 years or above;
- Hospitalized due to acute coronary syndrome;
- Able and willing to provide written informed consent and to comply with the study.
Exclusion
- Cardiac shock;
- Unstable heart failure;
- Beta-agonist therapy on a continuous or intermittent basis;
- Hypotension (BP\<90/60 mmHg) or bradycardia (HR\<50 bpm) with symptoms;
- Sick sinus syndrome;
- Ⅱ\~Ⅲ atrioventricular block;
- Killip \>Ⅱ;
- Suspected acute myocardial infarction with heart rate\<45 beats/min, P- R interval\>0.24 sec or systolic blood pressure \<100 mmHg;
- Existing contraindication for metoprolol or allergic to metoprolol or any excipients;
- Participation in another clinical study with an investigational product during the last 3 months;
- Previous enrolment in the present study;
- Subjects the investigator thinks not suitable for this study. E.g. cancer etc.;
- Inability to sign the informed consent form;
- Pregnancy or lactation.
Key Trial Info
Start Date :
February 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
July 30 2020
Estimated Enrollment :
1000 Patients enrolled
Trial Details
Trial ID
NCT03413410
Start Date
February 1 2018
End Date
July 30 2020
Last Update
July 19 2019
Active Locations (1)
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1
The General Hospital of PLA
Beijing, China, 100853