Status:
COMPLETED
Predicting Fluid Responsiveness Using Transiently Increased Intrathoracic Pressure in Mechanically Ventilated Patients
Lead Sponsor:
University of California, Davis
Conditions:
Fluid Reponsiveness
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this study is to identify in patients requiring active fluid resuscitation and mechanical ventilation for circulatory shock, can a controlled increase in intrathoracic pressure (either by ...
Detailed Description
Once an eligible subject is identified and written or telephone consent is obtained from the patient or surrogate as appropriate, we will record demographic data and clinical information including age...
Eligibility Criteria
Inclusion
- Mechanically ventilated
- Identified by treatment team as requiring intravenous fluid bolus
- Acute circulatory failure during admission (systolic blood pressure (SBP) ≤90 mmHg or mean arterial pressure (MAP) ≤70 mmHg or requiring vasopressors to maintain SBP \>90 mmHg or MAP \>70 mmHg, along with one or more of the following:
- urinary flow ≤0.5 mL/kg/min for ≥2 hours,
- heart rate ≥100 beats per minute
- presence of skin mottling
- blood lactate concentration ≥4 mmol/L
Exclusion
- Contraindication to fluid bolus
- Assynchrony Index \> 10%
- Clinically significant cardiac arrhythmia
- Severe valvular heart disease
- Chest tubes with air leak
- Abdominal compartment syndrome
- Pregnancy
- Concurrent nebulized medication or inhaled nitric oxide
- Transthoracic echogenicity unsuitable for measuring velocity-time integral of aortic blood flow (SVI)
- Prisoner
- Clinical brain death
- PEEP \> 15 cmH2O
Key Trial Info
Start Date :
December 27 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 13 2018
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT03413657
Start Date
December 27 2017
End Date
September 13 2018
Last Update
January 18 2020
Active Locations (1)
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1
University of California, Davis
Sacramento, California, United States, 95817