Status:
UNKNOWN
Transplantation of Umbilical Cord-derived Mesenchymal Stem Cells Via Different Routes
Lead Sponsor:
The First Affiliated Hospital of Dalian Medical University
Conditions:
Cerebral Palsy
Eligibility:
All Genders
2-18 years
Phase:
NA
Brief Summary
To preliminarily evaluate the efficacy and safety of umbilical cord-derived mesenchymal stem cells (UC-MSCs), and compare the efficacy of UC-MSCs administered through the intravenous, intrathecal, and...
Detailed Description
Cerebral palsy refers to a neurological disorder caused by a non-progressive brain injury or malformation that occurs in early childhood. It can result in central motor deficits, developmental retarda...
Eligibility Criteria
Inclusion
- Patients diagnosed with hypoxic/ischemic cerebral palsy, primarily including birth asphyxia and premature children
- Patients with spastic quadriplegia
- Patients with moderate to severe cerebral palsy, GMFM scores of 2-3
- Age at 2-18 years
- Provision of signed informed consent by legal representatives of the child prior to start of the study
Exclusion
- Those with systemic diseases that likely interfere with the treatment or child's compliance
- Those complicated by life-threatening diseases of any organ
- Those with brain deformity
- Those with uncontrolled epilepsy
- Those with abnormal behavior or mood disorders
- Those with allergies especially those who are allergic to blood products
- Those are infected with infectious diseases
- Those who had underwent a craniocerebral surgery in other clinical trials
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2020
Estimated Enrollment :
44 Patients enrolled
Trial Details
Trial ID
NCT03414697
Start Date
April 1 2018
End Date
December 1 2020
Last Update
January 30 2018
Active Locations (1)
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1
The First Affiliated Hospital of Dalian Medical University
Dalian, Liaoning, China, 116011