Status:
COMPLETED
Valchlor in the Treatment of Lichen Planopilaris
Lead Sponsor:
Mayo Clinic
Collaborating Sponsors:
Actelion
Conditions:
Lichen Planopilaris
Eligibility:
All Genders
18+ years
Phase:
PHASE2
Brief Summary
The primary objective of this study is to assess the potential effectiveness of once daily application of Valchlor in decreasing disease activity in patients with Lichen Planopilaris. The primary meas...
Detailed Description
This is a single arm, open label, exploratory study to evaluate the efficacy of Valchlor in the treatment of LPP. Subjects will be screened by the Department of Dermatology at the Mayo Clinic in Flori...
Eligibility Criteria
Inclusion
- Male and female patients 18 years or older.
- Biopsy proven diagnosis of Lichen Planopilaris
- Biopsy proven diagnosis of Fontal Fibrosing Alopecia (a clinical variant of LPP restricted to frontal scalp)
- Good general health as confirmed by medical history
- Patients who are willing and capable of cooperating to the extent and degree required by the protocol; and
- Patients who read and sign an approved informed consent for this study
Exclusion
- Vulnerable study population
- Pregnant or nursing women
- Women planning a pregnancy within the study period
- Active smokers
- Known history of adverse reaction to mechlorethamine
- Use of systemic immunosuppressive
- Presence of ulcerated scalp lesions
Key Trial Info
Start Date :
April 1 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 30 2019
Estimated Enrollment :
12 Patients enrolled
Trial Details
Trial ID
NCT03417141
Start Date
April 1 2018
End Date
August 30 2019
Last Update
January 28 2021
Active Locations (1)
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1
Mayo Clinic in Florida
Jacksonville, Florida, United States, 32224