Status:
UNKNOWN
Does Incremental Initiation of Haemodialysis Preserve Native Kidney Function?
Lead Sponsor:
East and North Hertfordshire NHS Trust
Collaborating Sponsors:
University of Hertfordshire
Conditions:
Kidney Failure
Dialysis
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Patients who start haemodialysis usually retain some natural kidney function for months or years after starting dialysis. Even a small amount of this natural kidney function can be helpful in reducing...
Detailed Description
This study is feasibility randomised controlled trial. 50 patients who have newly started on haemodialysis will be recruited into the study from 4 UK centres. Eligible patients will be approached pr...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Advanced renal failure due to underlying primary kidney disease and established as a new starter on haemodialysis within the previous 3 months
- Residual Kidney Function likely to permit twice weekly dialysis as defined by interdialytic urea clearance ≥3ml/min/1.73m2 BSA measured routinely as part of standard care
- Sufficient understanding of the study procedures and requirements including capacity for explicit agreement to be randomised to standard or incremental HD regimens
Exclusion
- Planned organ transplantation and already on another interventional trial within 3 months from study screening
- Anticipated requirement for high-volume ultrafiltration on dialysis (e.g. subjects with daily enteral or parenteral nutrition)
- Blood-borne virus positivity
- Subjects unable to comply with requirement for monthly interdialytic urine collection.
- Pregnancy
- Prognosis \<12 months as judged by PI
Key Trial Info
Start Date :
January 8 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 2 2019
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03418181
Start Date
January 8 2018
End Date
March 2 2019
Last Update
February 1 2018
Active Locations (1)
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1
East and North Hertfordshire NHS Trust (incorporating Mount Vernon Cancer Centre)
Stevenage, United Kingdom, SG1 4AB