Status:
COMPLETED
Carnosine Loading and Periodized Training in MS and HC
Lead Sponsor:
Hasselt University
Conditions:
Multiple Sclerosis
Exercise Therapy
Eligibility:
All Genders
18-75 years
Phase:
NA
Brief Summary
Increasing evidence favours exercise therapy as an efficient tool to counteract inactivity related secondary symptoms in MS. Furthermore, exercise therapy may affect MS-associated muscle contractile a...
Detailed Description
Pilot data from the (co-)applicants' laboratories suggest that EAE rats (animal MS model) and MS-patients suffer from significantly reduced muscle carnosine levels compared to healthy counterparts. Th...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- Diagnosis Multiple Sclerosis. Healthy control. Aged \>18y. Written informed consent.
- Exclusion criteria:
- Contraindications to perform moderate to high intensity exercise. Participation in another study. Experienced acute MS related exacerbation \<6 months prior to start of the study EDSS score \> 3.5
Exclusion
Key Trial Info
Start Date :
February 1 2017
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 30 2017
Estimated Enrollment :
45 Patients enrolled
Trial Details
Trial ID
NCT03418376
Start Date
February 1 2017
End Date
December 30 2017
Last Update
April 20 2020
Active Locations (1)
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1
Hasselt University
Diepenbeek, Limburg, Belgium, 3590