Status:
RECRUITING
FAZA PET/MRI Sarcoma
Lead Sponsor:
University Health Network, Toronto
Conditions:
Sarcoma
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a dual arm, single centre, investigator initiated study to investigate the use of FAZA-PET in combination with MRI. FAZA is an investigational radiotracer used in PET scans. FAZA PET/MRI will ...
Detailed Description
Mutliple studies show that hypoxia in sarcoma has been consistently associated with poor treatment outcomes. Subsequently, there has been a study that shows inhibition of hypoxia-induced transcription...
Eligibility Criteria
Inclusion
- Age ≥ 18 years
- Patients with either: high-risk extremity STS (g2-3, \> 10 cm largest dimension, and leiomyosarcoma, synovial sarcoma, malignant peripheral nerve sheath tumour, or undifferentiated pleomorphic sarcoma), or: high-risk RPS (g2-3, and leiomyosarcoma or dedifferentiated liposarcoma)
- Intention to treat using radiotherapy/chemotherapy/surgery according to the current treatment policies of the Sarcoma Site Group of PM
- A negative serum pregnancy test within the two-week interval immediately prior to PET-MR imaging, for women of child-bearing age
- Ability to provide written informed consent to participate in the study
Exclusion
- Previous radiotherapy to intended treatment volumes.
- Previous systemic therapy
- Active malignancy other than sarcoma
- Unable to remain supine for at least 60 minutes
- Pregnancy or breast feeding
- Age less than 18 years old
- Failure to provide written informed consent
- Contraindication for MR as per current institutional guidelines.
Key Trial Info
Start Date :
March 27 2018
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 1 2028
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT03418818
Start Date
March 27 2018
End Date
October 1 2028
Last Update
February 10 2025
Active Locations (1)
Enter a location and click search to find clinical trials sorted by distance.
1
University Health Network
Toronto, Ontario, Canada, L4W4C2