Status:
COMPLETED
Cardiovascular Mechanisms of Exercise Intolerance in Diabetes and the Role of Sex
Lead Sponsor:
University of Colorado, Denver
Collaborating Sponsors:
VA Eastern Colorado Health Care System
Conditions:
Type 2 Diabetes Mellitus
Healthy
Eligibility:
All Genders
30-55 years
Phase:
NA
Brief Summary
This study will define the relationship of cardiac, vascular function and skeletal muscle blood flow (individually and together) to cardiovascular exercise capacity in in men and women with and withou...
Detailed Description
It is well established that functional exercise capacity and peak oxygen uptake (VO2) are reduced in patients with type 2 diabetes mellitus (T2DM) compared with healthy counterparts. The mechanisms un...
Eligibility Criteria
Inclusion
- Men and women with and without type 2 diabetes
- BMI 25-40
- Sedentary subjects not participating in a regular exercise program (\<one bout of exercise/week)
Exclusion
- Documented cardiovascular disease
- Uncontrolled hypertension: disease systolic blood pressure (SBP) \> 150, diastolic blood pressure (DBP)\> 110
- Obstructive pulmonary disease or asthma
- Peripheral neuropathy
- Physical impairment that would limit exercise ability
- Subjects taking beta blockers, calcium channel blockers, insulin, or Thiazolidinediones (TZD)
- Current or past smoking within the last 1 years
- Current tobacco use
- Anemia
- Control HbA1c \> 5.7, T2DM HbA1c \> 9
- Pregnant, nursing or hormonal therapy (other than contraceptives)
- Peri or post-menopausal women
- Type 1 diabetes
- Hepatic or renal disease.
- Peptic ulcer disease.
Key Trial Info
Start Date :
February 7 2018
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 20 2023
Estimated Enrollment :
124 Patients enrolled
Trial Details
Trial ID
NCT03419195
Start Date
February 7 2018
End Date
March 20 2023
Last Update
July 12 2023
Active Locations (1)
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1
University of Colorado, Anschutz Medical Campus
Aurora, Colorado, United States, 80045